Today at Parkland Morning Report, we talked about the utility of adenosine deaminase (ADA) in evaluating a patient with a pleural effusion, especially if there is a concern for tuberculosis. The link below is an article from The Journal of Clinical Medicine Research, titled “Role of Adenosine Deaminase Estimation in Differentiation of Tuberculous and Non-tuberculous Exudative Pleural Effusions.”
Key points from the article:
- The authors looked at pleural fluid from 96 samples, divided into tuberculous (56 samples) and non-tuberculous groups (40 samples).
- All of the samples met Light’s Criteria to be considered an exudative effusion.
- All 56 samples from the tuberculous group had positive ADA test (>40 U/L). Only one sample from the non-tuberculous group had a positive ADA test.
- Authors conclude that ADA pleural fluid levels can play an important rule in differentiating tuberculous pleural effusions.
- ADA is considered to be a low cost test with rapid turnover.