It’s Anemia’s Brand

 Special thanks to Vishy for passing along this clinical pearl for the differential for anemia!

IT’S ANEMIA’S BRAND (based on MCV)

Microcytic
Iron deficiency anemia
Thalassemia – defective globin chain production
Sideroblastic anemia – hereditary, acquired (Etoh, INH, lead)

Normocytic
Anemia of chronic disease
Nephrogenic (decreased EPO)
Endocrine
Myleophthisis (marrow infiltration)
IV fluids – dilutional
Aplastic anemia – primary or drug induced
Sickle cell anemia

Macrocytic
B12 deficiency
Reticulocytosis – compensatory from hemolysis
Alcohol
Nutritional deficiency of folate
Drugs (DNA synthesis inhibitors, dihydrofolate reductase inhibitors)