NPR posted on their website an interactive webpage detailing the experiences of survivors of Ebola and those who lost their family members to the infection in the African village of Barkedu. The webpage consists of photos and audio interviews with members of the village. Click on the link below to check it out:
Oliver Sacks, one of the leading public intellectuals of the last half-century, says terminal cancer of the liver has left him with only months to live.
Sacks, a neurologist and author of books like Awakenings and The Man Who Mistook his Wife for a Hat, revealed his condition in an article about facing death that was published in the New York Times on Thursday.
“It is up to me now to choose how to live out the months that remain to me,” Sacks, 81, writes in the Times. “I have to live in the richest, deepest, most productive way I can.”
He says he will shun politics and nightly news to focus instead on himself, his friends, and his work–an autobiography is set to come out in the spring, and he says he has “several” other books in the works. He writes:
This is not indifference but…
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Periodic Fever Syndromes
- Familial Mediterranean Fever (FMF)
- TNF Receptor-1 Associated Periodic Syndrome (TRAPS)
- Hyperimmunoglobulin D syndrome (HIDS)
- Periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA)
- Cryopyrin-associated periodic syndrome (CAPS)
- Muckle-Wells syndrome (MWS)
- Neonatal-onset multisystem inflammatory disorder (NOMID)
- Familial cold autoinflammatory syndrome (FCAS)
Case challenge # 4 presented a 21 yo white male with recurrent fevers and joint pains. Symptoms started at age 10, episodes occur every 6 months. Fever episodes last about 2 weeks, also associated with periorbital edema and spreading rash on extremities. Father has similar symptoms and also developed renal failure and CHF in his 40s. On exam, he had a fever of 102.3 F, periorbital edema, patchy macular rash on extremities.
What is the most likely diagnosis in this case?
A) Familial Mediterranean Fever
B) TNF Receptor-1 associated periodic syndrome
C) Hyper IgD syndrome
E) Cryopyrin-associated periodic syndromes
Here are the results of the voting:
The patient has TNF Receptor-1 Associated Periodic Syndrome (TRAPS).
- Autosomal dominant, one of periodic fever syndromes
- First described in pt of Irish (Hibernian) origin
- Due to genetic defect in TNF receptor gene (TNFR1)
- Presents with fever of longer duration (5-20 days) plus abdominal pain, characteristic rash, conjunctivitis and periorbital edema
- 25% develop amyloidosis with renal or cardiac dz.