Tough case this week! Case Challenge #5 presented a 28 yo female with fever, cervical LAD, and atypical lymphs. Biopsy revealed necrotizing lymphadenitis with histiocytes, nuclear debris, and negative organism stains.
Which is the most likely diagnosis?
The correct answer is:
- Benign disease of young (women) with acute fevers and unilateral cervical LAD (esp posterior)
- Associated with uveitis, aseptic meningitis, HSM, rash and arthritis
- Often leukopenic with atypical lymphs
- Dx by biopsy showing preserved architecture, necrotizing histiocytic infiltrate with phagocytosed nuclear debris
Great job! Look forward to a easier case challenge next week 🙂