Answer to CC #5

Tough case this week! Case Challenge #5 presented a 28 yo female with fever, cervical LAD, and atypical lymphs.  Biopsy revealed necrotizing lymphadenitis with histiocytes, nuclear debris, and negative organism stains.

 Which is the most likely diagnosis?

KikuchiResults
The correct answer is:

Kikuchi’s Disease

  • Benign disease of young (women) with acute fevers and unilateral cervical LAD (esp posterior)
  • Associated with uveitis, aseptic meningitis, HSM, rash and arthritis
  • Often leukopenic with atypical lymphs
  • Dx by biopsy showing preserved architecture, necrotizing histiocytic infiltrate with phagocytosed nuclear debris

Great job! Look forward to a easier case challenge next week 🙂