Beyond Ferritin

Excellent Grand Rounds presentation today by Dr. Joseph Garcia, focused on HIF-2 signaling and the use of acetate to increase epo production in treatment of anemia. In his slides, he discussed the use of biomarkers beyond traditional iron studies (ferritin, transferrin, iron, etc.) to determine the etiology of a patient’s anemia. Among these, the soluble transferrin receptor (sTfR), is useful because it does not change in response to acute inflammation, making it useful in the diagnosis of anemia of chronic disease. The chart below summarizes the changes in sTfR levels in different settings of anemia:

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