“What’s that syndrome with erythema nodosum and sarcoidosis?”

Lofgren syndrome! Below is a quick 101 cheat sheet on Lofgren syndrome, check it out!

  • Lofgren syndrome is a form of acute sarcoidosis (not to be confused with Loffler’s syndrome)
  • Initially described in 1953 by Sven Halvar Lofgren, a Swedish clinician
  • More common in Scandinavian, Irish and African populations
  • The syndrome is comprised of the combination of
  • Erythema Nodosum
  • Hilar adenopathy
  • Migratory polyarthralgia
  • Fever
  • In men, more common to have bilateral ankle arthritis instead of EN
  • The combination of all features of Lofgren syndrome has a 95% specificity for sarcoidosis, allowing for clinical diagnosis without pathology
  • However, consider the ddx for EN and hilar adenopathy: primary TB, sarcoid, coccidiodomycosis, histo, blasto, yersiniosis and chlamydia
  • The syndrome is associated with a good prognosis
  • Some patients have spontaneous remission and others require only NSAIDs to control their symptoms
  • In one retrospective study of 80 patients, 67% were treated with NSAIDs and 41% with steroids and only 17% had a recurrence

“Cancer: The Emperor of All Maladies” Documentary Coming Soon!

On March 30th, PBS will air the documentary “Cancer: The Emperor of All Maladies” based on the Pulitzer prize winning book “Emperor of All Maladies: A Biography of Cancer” written by Dr. Siddhartha Mukherjee, an oncologist at Columbia University. It is a six-part, 3-hour documentary with the following synopsis below from the film’s website:

This ‘biography’ of cancer covers its first documented appearances thousands of years ago through the epic battles in the 20th century to cure, control and conquer it, to a radical new understanding of its essence. The series also features the current status of cancer knowledge and treatment —the dawn of an era in which cancer may become a chronic or curable illness rather than its historic death sentence in some forms.”

Check out the film’s trailer and a link to the book on Amazon below by clicking the picture:


emperor of all maladies