Answer to CC #11

Case Challenge #11 presented a 71 year old gentleman with lethargy, weight loss, and widespread lymphadenopathy with no palpable organomegaly. He has a polyclonal gammopathy and the following biopsy findings:

cc11 HCD

Which of the following is the most likely diagnosis?Screen Shot 2015-04-10 at 12.08.27 PM

The correct answer is:

Multicentric Castleman’s Disease!

  • Symptoms: serious infections, fevers, weight loss, fatigue, night sweats, and nerve damage that can cause weakness and numbness.
  • Labs: frequently see anemia, hypergammaglobulinemia.
  • Acts very much like lymphoma – in fact, about 20% of people with this disease eventually develop lymphoma.
  • Treatment may involve steroids, surgery, chemotherapy or even radiation therapy.

Thanks for playing, case challenge #12 will be posted next week!