#clinicalpearls: Hepatitis B & D

  • Hepatitis B
    • HBsAg → active infection
    • HBsAb → past infection or vaccination against hepatitis B
    • HBeAg → active replication of the virus
    • AntiHBc IgM → acute infection
    • AntiHBc IgG → chronic infection
    • Chronic, and carrier states will have positive HBsAg and Anti-HBcIgG. How can these two conditions be differentiated?
      • Chronic → Increased LFTs
      • Carrier → Normal LFTs
  • Hepatitis D: requires Hepatitis B infection to be present
    • Anti-HBc IgM + Hepatitis D virus → acute co-infection and will not worsen hepatitis
    • Anti-HBc IgG + Hepatitis D virus → acute super-infection and can cause fulminant hepatitis