D-dimer Primer

You know that the d-dimer does not always suggest VTE, but WHAT ELSE COULD IT BE?!

Non-pathological conditions associated with elevated D-dimer titers include:

  • Age (healthy elderly people)
  • Cigarette smoking
  • Functional impairment
  • Post-operatively
  • Pregnancy
  • Race (e.g. African Americans)

Pathological conditions associated with elevated D-dimer titers include:

  • Acute coronary syndromes
  • Acute upper gastrointestinal haemorrhage
  • Aortic dissection
  • Arterial or venous thromboembolism
  • Atrial fibrillation
  • Consumptive coagulopathy – DIC, VICC
  • Infection
  • Malignancy
  • Pre-eclampsia
  • Sickle cell disease
  • Stroke
  • Superficial thrombophlebitis
  • Trauma
To learn more about the d-dimer, check out yesterday’s quiz from JAMA. D-dimer PE quiz