AIDS Related Lymphomas

  • Since the implementation of HAART therapy, a cancer diagonsis is made in over 40% of HIV infected patients during the course of the HIV infection
  • Over 28% of HIV related deaths are attributable to malignancy
  • Three AIDS defining malignancies
    • Kaposi’s sarcoma
    • High grade non-Hodgkin lymphoma
    • Invasive cervical carcinoma
  • AIDS related NHL can be subdivided into systemic NHL, primary CNS lymphoma, and primary effusion lymphoma
  • Lymphoma in HIV positive patient is characterized by B symptoms, extranodal disease, involvement of unusual locations (body cavity, rectum, soft tissue) and advanced disease
  • Most common NHL subtypes seen in HIV patients: DLBCL, Burkitt lymphoma, plasmablastic lymphoma
  • EBV positivity is seen in Burkitt lymphoma, primary effusion lymphoma, plasmablastic lymphoma, primary CNS lymphoma
  • HHV positivity seen in primary effusion lymphoma, multicentric Castleman’s disease, Kaposi’s Sarcoma