UTSW Faculty’s Publication Featured in Medscape!

Congratulations to Dr. Ishak Mansi from the division of General Internal Medicine at UT Southwestern for his recently published article, “Statins and New-Onset Diabetes Mellitus and Diabetic Complications: A Retrospective Cohort Study of US Healthy Adults” in the Journal of General Internal Medicine. Dr. Mansi’s findings were featured on the frontpage of Medscape this past week and has gained a lot of attention. According to Dr. Mansi and the authors, this is one of the first studies to show a connection between statin use and risk of diabetes in a generally healthy group. Click on the links below to read the summary of the article’s findings as well as the abstract!

Statins and New-Onset Diabetes Mellitus and Diabetic Complications: A Retrospective Cohort Study of US Healthy Adults

Statins Linked to Diabetes and Complications in Healthy Adults (Medscape) 

Answer to CC #17

Case challenge #17 presented an 85-year-old Caucasian male with “bony protrusions” on his gums and the following histologic findings:

Casechallenge 17

Which of the following is the best initial treatment?

CC17 Voting

The correct answer is: IV Penicillin G

The image above reveals infection by a the filamentous, gram-positive, non-acid fast, anaerobic bacteria, ACTINOMYCES.

Background

  • Subacute-to-chronic bacterial infection caused by filamentous gram positive, non-acid fast, anaerobic bacteria
  • Most common clinical forms of actinomycosis are cervicofacial, thoracic, and abdominal
  • Endemic world-wide
  • Thoracic actinomycosis accounts for 15-20% of cases. Aspiration of oropharyngeal secretions containing actinomycetes is the usual mechanism of infection.

Clinical Presentation

  • Cervicofacial, thoracic, abdominal, and CNS infections:
  • Often present with: dry or productive cough, blood streaked sputum, shortness of breath, fevers, weight loss, fatigue, anorexia

Diagnosis

  • Direct identification and/or isolation of the organism from a clinical specimen
  • Sulfur granules

Management

  • Preferred regimen: Pen G IV for 2-6 weeks, then amoxicillin PO for 6-12 months
  • Doxycycline, minocycline, tetracycline, clindamycin, erythromycin, and cephalosporins have been proven to be effective in case reports

Case Challenge 18, next week!