Rebuilding heart muscle: The hypoxic bubble

Check out the recent Nature publication by Dr. Hesham Sadek‘s group in which they identify and characterize cycling cardiomyocytes in a novel transgenic mouse model. Their work was recently highlighted on KERA and highlights the role of hypoxia signalling and HIF1-alpha in maintaining cardiomyocyte proliferative capacity. This research suggests that adult mammals are capable of cardiac regeneration following ischemic injury and is an important step toward the ultimate goal: cellular therapies for human coronary ischemia!

Figure reprinted with permission by Nature Publishing Group