Necrotizing Sarcoid Granulomatosis

An excellent case of necrotizing sarcoid granulomatosis with lung and CNS involvement was presented at morning report on 7/9/2015. While necrotizing granulomas often raise the suspicion for infection and vasculitis, it is important to consider necrotizing sarcoid granulomatosis (NSG) as a possible alternative diagnosis. Currently the relationship of NSG to nodular or classical sarcoidosis remains unclear and there are several conflicting opinions surrounding possible overlap among these syndromes falling on a continuous spectrum of disease or if two separate entities exist. One thing is clear, however, that NSG remains a perplexing, rare diagnosis which lends itself to further research. #AMReport

Check out these review articles to learn more:

Four Decades of Necrotizing Sarcoid Granulomatosis: What Do We Know Now?

Neurosarcoidosis: diagnostic approaches and therapeutic strategies

Necrotizing Sarcoid Granulomatosis