A recently published article in JAMA addressed some updates in sepsis management and diagnosis. The report incorporated numerous randomized clinical trials in order to strengthen the recommendations. Key advances noted in the paper include focused ultrasound for early recognition of underlying contributors to hypoperfusion such as cardiogenic shock or hypovolemia and invasive monitoring in only a select group of patients. Sepsis protocols were found to have little advantage over management without a protocol in a number of studies and albumin/crystalloid solutions remain up for debate. An excellent algorithm is included in the paper.
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