Researchers Map the Genetic Evolution of Melanoma

Researchers at UCSF recently performed a detailed genetic analysis of 293 cancer-relevant genes in 37 primary melanomas and their adjacent precursor lesions. Unequivocally benign lesions, intermediate lesions, and intraepidermal or invasive melanoma were identified and characterized in reference to their respective driver mutations, BRAFNRAS & TERT and CDKN2A. Similar to colon cancer, melanoma exhibits a well conserved molecular oncogenesis, setting the stage for the formulation of refined criteria for diagnosis and prognostication. This model also identifies potential targets for pharmacological therapy and/or prevention.