Last week Dr. Skaug presented a fascinating case of recurrent lactic acidosis of unclear etiology. Here is a succinct review of the differential for lactic acidosis:
- Type A (Most Common): Tissue hypoperfusion resulting from hypovolemia, cardiac failure, sepsis, or cardiopulmonary arrest.
- Type B : Evidence of systemic hypoperfusion is not apparent
- Diabetes (Metformin Related and D-Lactate)
- Mitochondrial Dysfunction (Drugs, Sepsis)
- D Lactate (Excessive gut fermentation producing D lactate)
For further information please reference this excellent review article in CHEST