Great discussion on inflammatory myopathies with Dr. Kazi during today’s CUH morning report!
Did you know that patients with inflammatory myopathies such as dermatomyositis/polymyositis with antisynthetase antibodies (e.g., Anti-Jo-1) have high risk of developing interstitial lung disease?
Antisynthetase syndrome is defined as:
- Presence of at least 1 anti-synthetase Ab
- ≥1 of the following: 1) inflammatory myopathy; 2) inflammatory polyarthritis; 3) interstitial lung disease.
Other features to support the diagnosis include: “mechanic’s hands”, Raynaud’s, fevers
Certain antisynthetase antibodies (Anti-PL-12) are associated with ILD as the dominant clinical feature.
Links to a couple NEJM articles below: